全文获取类型
收费全文 | 1036篇 |
免费 | 120篇 |
国内免费 | 164篇 |
出版年
2024年 | 3篇 |
2023年 | 25篇 |
2022年 | 23篇 |
2021年 | 44篇 |
2020年 | 49篇 |
2019年 | 56篇 |
2018年 | 46篇 |
2017年 | 45篇 |
2016年 | 49篇 |
2015年 | 43篇 |
2014年 | 71篇 |
2013年 | 106篇 |
2012年 | 57篇 |
2011年 | 74篇 |
2010年 | 65篇 |
2009年 | 61篇 |
2008年 | 71篇 |
2007年 | 57篇 |
2006年 | 58篇 |
2005年 | 45篇 |
2004年 | 45篇 |
2003年 | 29篇 |
2002年 | 28篇 |
2001年 | 15篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1998年 | 20篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 7篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有1320条查询结果,搜索用时 31 毫秒
101.
102.
李淑清 《Acta Botanica Sinica》2002,(10)
知识经济作为一种以知识和信息为基础的经济 ,将对整个社会的经济生活产生重大而深远的影响。作为协调经济活动过程的管理 ,也必将发生相应的变化。跨世纪的商业经济管理人才必须具备一定的素质、能力和知识结构 ,为此高等院校要进行相应的教学改革 ,从而培养出适应未来社会经济管理的人才 相似文献
103.
The age-specific fecundity of Trichogramma evanescens Westwood and T. cacoeciae Marchal (Hymenoptera: Trichogrammatidae) with Ephestia elutella (Hübner) (Lepidoptera: Pyralidae: Phycitinae) as host and the life span of the adults with and without hosts was determined at 20, 26, 30 and 35 °C and 75 ±5% r.h. in the laboratory. At 35 °C, no progeny emerged. The availability of hosts prolonged the longevity in both species. Longevity, percentage of parasitism, fecundity, and the intrinsic rate of natural increase were higher in T. evanescens than in T. cacoeciae. Trichogramma evanescens is expected to be more effective than T. cacoeciae for use in biological control of Ephestia spp., especially at low and high temperatures. 相似文献
104.
105.
106.
Island endemic species are expected to have lower dispersal ability than their non-endemic congeners. Several studies have demonstrated differences in diaspore morphology between endemic species and their non-endemic congeners. It is, however, relatively difficult to translate the differences in morphology of the diaspores into differences in dispersal ability. To avoid this problem, we measured directly dispersal values (anemo-, hydro-, exozoo- and endozoo-chory) of 27 pairs of closely related endemic and non-endemic species from Canary Islands. We did not explicitly support the hypothesis about the loss of dispersal ability of island species. The comparison of pairs of endemic and non-endemic species showed the reduction in dispersal potential only for endozoochory. In many cases, endemic species had, in fact, the same or better dispersal ability than their non-endemic congeners. Higher dispersal ability of endemic species could have been evolved as a consequence of species subsequent dispersal to neighboring islands. As a support for this we found that the endemic species dispersing better than their non-endemic congeners also occupy more islands within the archipelago. We conclude that reduction of dispersal ability of species on islands may not be as general as previously expected and we need to take into account multiple species traits to understand the possible evolution of species dispersal potential. 相似文献
107.
Jan J.J. Aalberts J. Peter van Tintelen Lilian J. Meijboom Annette Polko Jan D.H. Jongbloed Henriette van der Wal Gerard Pals Jan Osinga Janneke Timmermans Julie de Backer Marian K. Bakker Dirk J. van Veldhuisen Robert M.W. Hofstra Barbara J.M. Mulder Maarten P. van den Berg 《Gene》2014
Cardiovascular manifestations in patients with Marfan syndrome (MFS) are related to aortic and valvular abnormalities. However, dilatation of the left ventricle (LV) can occur, even in the absence of aortic surgery or valvular abnormalities. We evaluated genetic characteristics of patients with MFS with LV dilatation. One hundred eighty-two patients fulfilling the MFS criteria, without valvular abnormalities or previous aortic surgery, with a complete FBN1 analysis, were studied. FBN1 mutations were identified in over 81% of patients. Twenty-nine patients (16%) demonstrated LV dilatation (LV end diastolic diameter corrected for age and body surface area > 112%). FBN1-positive patients carrying a non-missense mutation more often had LV dilatation than missense mutation carriers (14/74 versus 5/75; p < 0.05). Finally, FBN1-negative MFS patients significantly more often demonstrated LV dilatation than FBN1-positive patients (10/33 versus 19/149; p < 0.05). It is concluded that LV dilatation in MFS patients is more often seen in patients with a non-missense mutation and in those patients without an FBN1 mutation. Therefore physicians should be aware of the possibility of LV dilatation in these patients even in the absence of valvular pathology. 相似文献
108.
Eric J. Sturman Timothy J. Rydel Meiying Zheng Jeffrey W. Seale Sonya Franklin 《Protein science : a publication of the Protein Society》2014,23(11):1491-1497
For almost half a century, the structure of the full‐length Bacillus thuringiensis (Bt) insecticidal protein Cry1Ac has eluded researchers, since Bt‐derived crystals were first characterized in 1965. Having finally solved this structure we report intriguing details of the lattice‐based interactions between the toxic core of the protein and the protoxin domains. The structure provides concrete evidence for the function of the protoxin as an enhancer of native crystal packing and stability. 相似文献
109.
Matheus R. de Mendonça Leandro G. Rizzi Vinicius Contessoto Vitor B. P. Leite Nelson A. Alves 《Proteins》2014,82(1):119-129
A number of studies have demonstrated that simple elastic network models can reproduce experimental B‐factors, providing insights into the structure–function properties of proteins. Here, we report a study on how to improve an elastic network model and explore its performance by predicting the experimental B‐factors. Elastic network models are built on the experimental coordinates, and they only take the pairs of atoms within a given cutoff distance rc into account. These models describe the interactions by elastic springs with the same force constant. We have developed a method based on numerical simulations with a simple coarse‐grained force field, to attribute weights to these spring constants. This method considers the time that two atoms remain connected in the network during partial unfolding, establishing a means of measuring the strength of each link. We examined two different coarse‐grained force fields and explored the computation of these weights by unfolding the native structures. Proteins 2014; 82:119–129. © 2013 Wiley Periodicals, Inc. 相似文献
110.
Gaussian network model (GNM) modes of motion are calculated to a dataset of h emoglobin (Hb) structures and modes with dynamics similarity to the T state are multiply aligned. The sole criterion for the alignment is the mode shape itself and not sequence or structural similarity. Standard deviation (SD) of the GNM value score along the alignment is calculated, regions with high SD are defined as dynamically variable. The analysis shows that the α1β1/α2β2 interface is a dynamically variable region but not the α1β2/α2β1 and the α1α2/β1β2 interfaces. The results are in accordance with the T → R2 transition of Hb. We suggest that dynamically variable regions are regions that are likely to undergo structural change in the protein upon binding, conformational transition, or any other relevant chemical event. The represented technique of multiple dynamics ‐ based alignment of modes is novel and may offer a new insight in proteins ' dynamics to function relation. Proteins 2014; 82:2097–2105. © 2014 Wiley Periodicals, Inc. 相似文献